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Literature summary for 3.4.21.91 extracted from

  • Frecer, V.; Miertus, S.
    Design, structure-based focusing and in silico screening of combinatorial library of peptidomimetic inhibitors of Dengue virus NS2B-NS3 protease (2010), J. Comput. Aided Mol. Des., 24, 195-212.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Bz-Nle-(3-amino)-Phe-(3-imino)-Phe-(3,4-dimethoxy)-Phe
-
Dengue virus type 2
Bz-Nle-(3-guanidino)-Phe-(4-guanidino)-Phe-(4-guanidino)-Phe
-
Dengue virus type 2
Bz-Nle-(4-amino)-Phe-(3-guanidino)-Phe-(4-amino)-Phe
-
Dengue virus type 2
Bz-Nle-(4-amino)-Phe-(3-guanidino)-Phe-Arg
-
Dengue virus type 2
Bz-Nle-(4-amino)-Phe-(3-imino)-Phe-Arg
-
Dengue virus type 2
Bz-Nle-(4-amino)-Phe-(4-guanidino)-Phe-Trp
-
Dengue virus type 2
Bz-Nle-Arg-(3-guanidino)-Phe-(4-amino)-Phe
-
Dengue virus type 2
Bz-Nle-His-(3-guanidino)-Phe-(4-guanidino)-Phe
-
Dengue virus type 2
Bz-Nle-His-(3-guanidino)-Phe-beta-(2-naphthyl)-Ala
-
Dengue virus type 2
Bz-Nle-His-(3-imino)-Phe-Arg
-
Dengue virus type 2
Bz-Nle-His-(4-guanidino)-Phe-(4-guanidino)-Phe
-
Dengue virus type 2
Bz-Nle-His-(4-guanidino)-Phe-Trp
-
Dengue virus type 2
Bz-Nle-homo-His-(3-guanidino)-Phe-(4-guanidino)-Phe
-
Dengue virus type 2
Bz-Nle-homoHis-(3-guanidino)-Phe-Arg
-
Dengue virus type 2
Bz-Nle-homoHis-(4-guanidino)-Phe-(4-phenyl)-Phe
-
Dengue virus type 2
Bz-Nle-Lys-Arg-Trp
-
Dengue virus type 2

Organism

Organism UniProt Comment Textmining
Dengue virus type 2
-
-
-

Synonyms

Synonyms Comment Organism
NS3 protease
-
Dengue virus type 2
NS3pro
-
Dengue virus type 2

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0001
-
Bz-Nle-His-(3-guanidino)-Phe-(4-guanidino)-Phe predicted inhibition constant, pH and temperature not specified in the publication Dengue virus type 2
0.0002
-
Bz-Nle-(4-amino)-Phe-(3-guanidino)-Phe-(4-amino)-Phe predicted inhibition constant, pH and temperature not specified in the publication Dengue virus type 2
0.0005
-
Bz-Nle-homo-His-(3-guanidino)-Phe-(4-guanidino)-Phe predicted inhibition constant, pH and temperature not specified in the publication Dengue virus type 2
0.0008
-
Bz-Nle-His-(3-guanidino)-Phe-beta-(2-naphthyl)-Ala predicted inhibition constant, pH and temperature not specified in the publication Dengue virus type 2
0.0009
-
Bz-Nle-His-(4-guanidino)-Phe-Trp predicted inhibition constant, pH and temperature not specified in the publication Dengue virus type 2
0.0013
-
Bz-Nle-(3-amino)-Phe-(3-imino)-Phe-(3,4-dimethoxy)-Phe predicted inhibition constant, pH and temperature not specified in the publication Dengue virus type 2
0.0014
-
Bz-Nle-homoHis-(4-guanidino)-Phe-(4-phenyl)-Phe predicted inhibition constant, pH and temperature not specified in the publication Dengue virus type 2
0.0015
-
Bz-Nle-Arg-(3-guanidino)-Phe-(4-amino)-Phe predicted inhibition constant, pH and temperature not specified in the publication Dengue virus type 2
0.0016
-
Bz-Nle-Lys-Arg-Trp predicted inhibition constant, pH and temperature not specified in the publication Dengue virus type 2
0.0017
-
Bz-Nle-His-(3-imino)-Phe-Arg predicted inhibition constant, pH and temperature not specified in the publication Dengue virus type 2
0.0017
-
Bz-Nle-(4-amino)-Phe-(3-imino)-Phe-Arg predicted inhibition constant, pH and temperature not specified in the publication Dengue virus type 2
0.0018
-
Bz-Nle-His-(4-guanidino)-Phe-(4-guanidino)-Phe predicted inhibition constant, pH and temperature not specified in the publication Dengue virus type 2
0.0018
-
Bz-Nle-(4-amino)-Phe-(4-guanidino)-Phe-Trp predicted inhibition constant, pH and temperature not specified in the publication Dengue virus type 2
0.0018
-
Bz-Nle-(3-guanidino)-Phe-(4-guanidino)-Phe-(4-guanidino)-Phe predicted inhibition constant, pH and temperature not specified in the publication Dengue virus type 2
0.0019
-
Bz-Nle-homoHis-(3-guanidino)-Phe-Arg predicted inhibition constant, pH and temperature not specified in the publication Dengue virus type 2
0.002
-
Bz-Nle-(4-amino)-Phe-(3-guanidino)-Phe-Arg predicted inhibition constant, pH and temperature not specified in the publication Dengue virus type 2