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Literature summary for 3.4.21.91 extracted from

  • Schrauf, S.; Schlick, P.; Skern, T.; Mandl, C.W.
    Functional analysis of potential carboxy-terminal cleavage sites of tick-borne encephalitis virus capsid protein (2008), J. Virol., 82, 2218-2229.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
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Flavivirus sp. 16020
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Organism

Organism UniProt Comment Textmining
Flavivirus sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protein C of tick-borne encephalitis virus + H2O the protein contains two amino acid sequence motifs within the carboxy-terminal region that match the canonical NS2B/3 recognition site. The downstream site is necessary and sufficient for efficient cleavage and virion assembly. In contrast, the upstream site is dispensable and placed in a structural context that renders it largely inaccessible to the viral protease. The NS2B/3 protease predominantly uses the downstream cleavage motif R95-R96-S97 for cleavage Flavivirus sp. ?
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?

Synonyms

Synonyms Comment Organism
NS2B/3 protease
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Flavivirus sp.