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Literature summary for 3.4.21.91 extracted from

  • Chambers, T.J.; Nestorowicz, A.; Rice, C.M.
    Mutagenesis of the yellow fever virus NS2B/3 cleavage site: determinants of cleavage site specificity and effects on polyprotein processing and viral replication (1995), J. Virol., 69, 1600-1605.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
using recombinant vaccinia virus expression system Yellow fever virus
Yellow fever virus polyprotein (NS2B protein and NS3 proteinase domain) Yellow fever virus

Organism

Organism UniProt Comment Textmining
Yellow fever virus
-
 i.e. YF
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NS2B-3181-polyproteins + H2O effect of mutations within Gly-Ala-Arg-Arg-+-Ser sequence on cis-cleavage (mutations at P1', P1, P2, P3 and P4), the term-+- depicts the point of cleavage Yellow fever virus ?
-
 ?
YF17D virus protein + H2O cleavage site: Gln-Gln-Arg-+-Ser, i.e. 4A/2K site, this cleavage is prerequisite for processing at the downstream signalase site, determinants of cleavage site specificity for 2B/3 cleavage (site: Gly-Ala-Arg-Arg-+-Ser), the term-+- depicts the point of cleavage Yellow fever virus ?
-
 ?