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Literature summary for 3.4.21.89 extracted from

  • Crauste, C.; Froeyen, M.; Anne, J.; Herdewijn, P.
    Asymmetric synthesis of new beta-lactam lipopeptides as bacterial signal peptidase I inhibitors (2011), Eur. J. Org. Chem., 2011, 3437-3449.
No PubMed abstract available
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Inhibitors

Inhibitors Comment Organism Structure
(3S)-3-((1R)-1-[(N-decanoyl-L-prolyl-L-threonyl-L-alanyl-L-asparaginyl)amino]ethyl)azetidin-2-one beta-lactam lipopeptide, 57% inhibition at 0.1 mM Staphylococcus aureus
(3S)-3-((1S)-1-[(N-decanoyl-L-prolyl-L-threonyl-L-alanyl-L-asparaginyl)amino]ethyl)azetidin-2-one beta-lactam lipopeptide, 47% inhibition at 0.1 mM Staphylococcus aureus
benzyl (2S,5R,6S)-6-[(N-decanoyl-L-prolyl-L-threonyl-L-alanyl-L-asparaginyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]-heptane-2-carboxylate beta-lactam lipopeptide, 36% inhibition at 0.1 mM Staphylococcus aureus
decanoyl-L-prolyl-L-threonyl-L-alanyl-L-asparaginyl-carboxamide beta-lactam lipopeptide, 60% inhibition at 100 mM, removal of the beta-lactam moiety results in a loss of activity Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Synonyms

Synonyms Comment Organism
SpsB
-
 Staphylococcus aureus