Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a null mutant of SPase I is not possible, suggesting that SPase I is an essential gene for parasite survival. The obtained heterozygote mutant by disrupting one allele of SPase I show significantly reduced level of infectivity in bone marrow-derived macrophages. The heterozygote mutants are unable to cause cutaneous lesion in susceptible BALB/c mice. Comparison of in vivo infectivity potential of DELTAspase::NEO/SPase heterozygote mutant and wild-type parasites, overview | Leishmania major |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania major | - |
strain MHOM/IL/81, isolated from footpad lesions of infected BALB/c mice | - |
Leishmania major MHOM/IL/80/Friedlin | - |
strain MHOM/IL/81, isolated from footpad lesions of infected BALB/c mice | - |
Synonyms | Comment | Organism |
---|---|---|
signal peptidase type I | - |
Leishmania major |
Spase I | - |
Leishmania major |
General Information | Comment | Organism |
---|---|---|
physiological function | SPase I is responsible for removing the signal peptide from secretory pre-proteins and releasing mature proteins to cellular or extra-cellular space. SPase I may have an important role in Leishmania infectivity, e.g. in differentiation and survival of amastigotes | Leishmania major |