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Literature summary for 3.4.21.89 extracted from

  • Pene, V.; Hernandez, C.; Vauloup-Fellous, C.; Garaud-Aunis, J.; Rosenberg, A.R.
    Sequential processing of hepatitis C virus core protein by host cell signal peptidase and signal peptide peptidase: a reassessment (2009), J. Viral Hepat., 16, 705-715.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(Z-LL)2-ketone completely abolishes signal peptide peptidase-catalysed maturation of p23 to p21 in the case of wild-type Homo sapiens
L685,458 exerts only a slight effect on signal peptide peptidase-catalysed maturation of p23 to p21 in the case of wild-type, but it almost completely abolishes this process in the case of the Con1/C3/VLV replicon Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information Huh-7.5.1 cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information signal peptide peptidase-catalysed liberation of mature core protein is absolutely dependent on prior cleavage by SP at the correct core-E1 site to generate the complete form of core protein Homo sapiens ?
-
?
p23 + H2O
-
Homo sapiens p21 + ?
-
?

Synonyms

Synonyms Comment Organism
Signal peptidase
-
Homo sapiens
Signal peptide peptidase
-
Homo sapiens
SP
-
Homo sapiens
SPP
-
Homo sapiens