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Literature summary for 3.4.21.89 extracted from
- The role of the conserved box E residues in the active site of the Escherichia coli type I signal peptidase (2000), J. Biol. Chem., 275, 6490-6498.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D273A | site directed scanning mutagenesis | Escherichia coli |
| D273A/R146A | site directed scanning mutagenesis | Escherichia coli |
| D273A/R146A/T94V | site directed scanning mutagenesis | Escherichia coli |
| D273N | site directed scanning mutagenesis | Escherichia coli |
| D280A | site directed scanning mutagenesis | Escherichia coli |
| D280E | site directed scanning mutagenesis | Escherichia coli |
| G272A | site directed scanning mutagenesis | Escherichia coli |
| G278A | site directed scanning mutagenesis | Escherichia coli |
| G285A | site directed scanning mutagenesis | Escherichia coli |
| N274A | site directed scanning mutagenesis | Escherichia coli |
| N277A | site directed scanning mutagenesis | Escherichia coli |
| N277D | site directed scanning mutagenesis | Escherichia coli |
| R146A | site directed scanning mutagenesis | Escherichia coli |
| R146M | site directed scanning mutagenesis | Escherichia coli |
| R282M | site directed scanning mutagenesis | Escherichia coli |
| T94V | site directed scanning mutagenesis | Escherichia coli |
| T94V/R146A | site directed scanning mutagenesis | Escherichia coli |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | integral membrane protein | Escherichia coli | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| signal peptides from preproteins + H2O | Escherichia coli | - |
mature proteins | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-ompA-nuclease + H2O | - |
Escherichia coli | ompA-nuclease + ? | - |
? | |
| signal peptides from preproteins + H2O | - |
Escherichia coli | mature proteins | - |
? | |
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Release 2023.1 (January 2023)
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