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Literature summary for 3.4.21.89 extracted from

  • Dalbey, R.E.
    Leader peptidase (1991), Mol. Microbiol., 51, 2855-2860.
    View publication on PubMed
Search for more literature for 3.4.21.89

Inhibitors

Inhibitors Comment Organism Structure
additional information Ser90 and Asp153 are essential for catalysis Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane integral membrane protein Escherichia coli 16020
-
membrane the enzyme spans the membrane twice, with its large carboxyl-terminal domain protruding into the periplasm Escherichia coli 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli the enzyme removes amino-terminal leader peptides from exported proteins after they have crossed the plasma membrane ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cleavable pre-proteins must have small residues at-1 and a small or aliphatic residue at-3 (with respect to the cleavage site) Escherichia coli ?
-
 ?
additional information the enzyme removes amino-terminal leader peptides from exported proteins after they have crossed the plasma membrane Escherichia coli ?
-
 ?