Cloned (Comment) | Organism |
---|---|
19 kDa subunit encoded by SEC11 gene | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | not inhibited by classical protease inhibitors such as phenylmethyl sulfonyl fluoride, tosyl-amido-2-phenylethylchloromethylketone, EDTA, o-phenanthroline, N-ethylmaleimide, dinitrophenol, carboxyphenanthroline, or 2,6-pyridinecarboxylic acid | Escherichia coli | |
Signal peptides that include a Pro residue at position +1 | - |
Escherichia coli |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | integral component of the cytoplasmic membrane | Escherichia coli | 5737 | - |
membrane | integral membrane protein | Gallus gallus | 16020 | - |
membrane | integral membrane protein | Escherichia coli | 16020 | - |
membrane | integral membrane protein | Saccharomyces cerevisiae | 16020 | - |
mitochondrion | inner membrane | Saccharomyces cerevisiae | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32000 | - |
active monomer, SDS-PAGE | Pseudomonas fluorescens |
36000 | - |
active monomer, SDS-PAGE | Salmonella enterica subsp. enterica serovar Typhimurium |
37000 | - |
active monomer, SDS-PAGE | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
signal peptides from preproteins + H2O | Salmonella enterica subsp. enterica serovar Typhimurium | - |
mature proteins | - |
? | |
signal peptides from preproteins + H2O | Escherichia coli | - |
mature proteins | - |
? | |
signal peptides from preproteins + H2O | Pseudomonas fluorescens | - |
mature proteins | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Gallus gallus | - |
- |
- |
Pseudomonas fluorescens | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Saccharomyces cerevisiae | - |
yeast | - |
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
Cleavage of hydrophobic, N-terminal signal or leader sequences | mechanism | Gallus gallus | |
Cleavage of hydrophobic, N-terminal signal or leader sequences | mechanism | Escherichia coli | |
Cleavage of hydrophobic, N-terminal signal or leader sequences | mechanism | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | specificity overview | Gallus gallus | ? | - |
? | |
additional information | specificity overview | Escherichia coli | ? | - |
? | |
additional information | specificity overview | Saccharomyces cerevisiae | ? | - |
? | |
additional information | cleavage of E. coli enzyme requires a small residue at-1 and a small or aliphatic residue at-3, presence of a helix breaker allows the pre-protein to bind with higher affinity, signal peptides that include a Pro residue at position-1 are not cleaved in E. coli | Escherichia coli | ? | - |
? | |
signal peptides from preproteins + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | mature proteins | - |
? | |
signal peptides from preproteins + H2O | - |
Escherichia coli | mature proteins | - |
? | |
signal peptides from preproteins + H2O | - |
Pseudomonas fluorescens | mature proteins | - |
? |