Literature summary for 3.4.21.84 extracted from

Kawabata, S.; Muta, T.; Iwanaga, S.
Limulus coagulation factor C (2004), Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press, 2nd. ed., 1740-1742.

No PubMed abstract available

Search for more literature for 3.4.21.84

Inhibitors

Inhibitors	Comment	Organism	Structure
antithrombin III	-	Tachypleus sp.
benzamidine	above 20 mM	Tachypleus sp.
DFP	-	Tachypleus sp.
leupeptin	above 0.2 mM	Tachypleus sp.
LICI-1	the serpin specifically inhibits factor Cbar	Tachypleus sp.
additional information	no inhibition by alpha2-plasmin inhibitor	Tachypleus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Limulus clotting factor B	Tachypleus sp.	active factor Cbar selectively cleaves the Arg103-/-Ser104 and Ile124-/-Ile125 bonds in proenzyme factor B to form factor Bbar, which then activates proclotting enzyme to clotting enzyme. The resulting clotting enzyme acts on coagulogen, causing the formation of an insoluble coagulin gel	Limulus clotting factor Bbar	-	?

Organism

Organism	UniProt	Comment	Textmining
Tachypleus sp.	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	the proenzyme Limulus coagulation factor C is autocatalytically converted to its active form, factor Cbar	Tachypleus sp.

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Limulus clotting factor B	active factor Cbar selectively cleaves the Arg103-/-Ser104 and Ile124-/-Ile125 bonds in proenzyme factor B to form factor Bbar, which then activates proclotting enzyme to clotting enzyme. The resulting clotting enzyme acts on coagulogen, causing the formation of an insoluble coagulin gel	Tachypleus sp.	Limulus clotting factor Bbar	-	?
Limulus clotting factor B	active factor Cbar selectively cleaves the Arg103-/-Ser104 and Ile124-/-Ile125 bonds in proenzyme factor B to form factor Bbar, which then activates proclotting enzyme to clotting enzyme. The resulting clotting enzyme acts on coagulogen, causing the formation of an insiluble coagulin gel	Tachypleus sp.	Limulus clotting factor Bbar	-	?

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Release 2023.1 (January 2023)