Literature summary for 3.4.21.79 extracted from

Kumar, A.; Perdomo, M.F.; Kantele, A.; Hedman, L.; Hedman, K.; Franssila, R.
Granzyme B mediated function of parvovirus B19-specific CD4+ T cells (2015), Clin. Transl. Immunology, 4, e39 .

Search for more literature for 3.4.21.79

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	the enzyme is secreted	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P10144	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
peripheral blood mononuclear cell	B19, HBoV1 and Candida albicans antigens are all found to induce peripheral blood mononuclear cell (PBMC) to secrete GrB in 30 parvovirus B19-seropositive and 22 parvovirus B19-seronegative subjects	Homo sapiens	-
T-lymphocyte	CD4+ cell	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
GrB	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	cytotoxic CD4+ cells have a part in controlling chronic viral infections such as EBV, CMV and HIV, they secrete granzyme B and perforin after pathogen induction. Direct cytotoxicity of parvovirus B19-specific CD4+ cells versus GrB secretion among seven parvovirus B19-seropositive subjects, overview. Pathogenetic role of these B19-specific CD4+ T cells secreting GrB (and possibly IL-17) in autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)	Homo sapiens

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Release 2023.1 (January 2023)