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Literature summary for 3.4.21.79 extracted from

  • Salti, S.M.; Hammelev, E.M.; Grewal, J.L.; Reddy, S.T.; Zemple, S.J.; Grossman, W.J.; Grayson, M.H.; Verbsky, J.W.
    Granzyme B regulates antiviral CD8+ T cell responses (2011), J. Immunol., 187, 6301-6309.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine granzyme B-deficient mice, and to a lesser extent perforin-deficient mice, exhibit a significant increase in the number of Ag-specific CD8+ T cells in the lungs and draining lymph nodes of virally infected animals. Viral titers in granzyme B-deficient mice are similar to wild-type mice and significantly less than perforin-deficient mice. Regulatory T cells from wild-type mice express high levels of granzyme B in response to infection, and depletion of regulatory T cells from these mice results in an increase in the number of Ag-specific CD8+ T cells, similar to that observed in granzyme B-deficient mice. Granzyme B-deficient regulatory T cells display defective suppression of CD8+ T cell proliferation in vitro Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 infected with Sendai virus
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General Information

General Information Comment Organism
physiological function granzyme B-deficient mice, and to a lesser extent perforin-deficient mice, exhibit a significant increase in the number of Ag-specific CD8+ T cells in the lungs and draining lymph nodes of virally infected animals. Viral titers in granzyme B-deficient mice are similar to wild-type mice and significantly less than perforin-deficient mice. Regulatory T cells from wild-type mice express high levels of granzyme B in response to infection, and depletion of regulatory T cells from these mice results in an increase in the number of Ag-specific CD8+ T cells, similar to that observed in granzyme B-deficient mice. Granzyme B-deficient regulatory T cells display defective suppression of CD8+ T cell proliferation in vitro Mus musculus