Literature summary for 3.4.21.79 extracted from

Haile, Y.; Simmen, K.C.; Pasichnyk, D.; Touret, N.; Simmen, T.; Lu, J.Q.; Bleackley, R.C.; Giuliani, F.
Granule-derived granzyme B mediates the vulnerability of human neurons to T cell-induced neurotoxicity (2011), J. Immunol., 187, 4861-4872.

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Application

Application	Comment	Organism
medicine	human neurons are selectively susceptible to granzyme B isolated from cytotoxic T cell granules. In vitro, purified human GrB induces neuronal death to the same extent as the whole activated T cell population. Following internalization through various parts of neurons, GrB accumulates in the neuronal soma. Within the cell body, GrB diffuses out of endosomes possibly through a perforin-independent mechanism and induces subsequent activation of caspases and cleavage of a-tubulin. Inhibition of caspase-3, a substrate for GrB, significantly reduces GrB-mediated neurotoxicity. Treatment of neurons with mannose-6-phosphate prevents GrB entry and inhibits GrB-mediated neuronal death	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Expression

Organism	Comment	Expression
Homo sapiens	expression of GrB mRNA is upregulated in active lesions of multiple sclerosis patients and in activated T cells	up

General Information

General Information	Comment	Organism
physiological function	human neurons are selectively susceptible to granzyme B isolated from cytotoxic T cell granules. In vitro, purified human GrB induces neuronal death to the same extent as the whole activated T cell population. Following internalization through various parts of neurons, GrB accumulates in the neuronal soma. Within the cell body, GrB diffuses out of endosomes possibly through a perforin-independent mechanism and induces subsequent activation of caspases and cleavage of a-tubulin. Inhibition of caspase-3, a substrate for GrB, significantly reduces GrB-mediated neurotoxicity. Treatment of neurons with mannose-6-phosphate prevents GrB entry and inhibits GrB-mediated neuronal death	Homo sapiens

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Release 2023.1 (January 2023)