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Literature summary for 3.4.21.79 extracted from

  • Hartmann, W.; Marsland, B.J.; Otto, B.; Urny, J.; Fleischer, B.; Korten, S.
    A novel and divergent role of granzyme A and B in resistance to helminth infection (2011), J. Immunol., 186, 2472-2481.
    View publication on PubMed

Application

Application Comment Organism
medicine proinflammatory gzmA and anti-inflammatory gzmB are novel modulators of the Th1/2 balance and defense in helminth infection Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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General Information

General Information Comment Organism
physiological function in filarial infection with Litomosoides sigmodontis, worm loads are significantly reduced in gzmA/gzmB and in gzmB knockout mice during the whole course of infection, but enhanced only early in gzmA knockout compared with wild-type mice. GzmA/gzmB deficiency is associated with a defense-promoting Th2 cytokine and Ab shift, enhanced early inflammatory gene expression, and a trend of reduced alternatively activated macrophage induction Mus musculus