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Literature summary for 3.4.21.79 extracted from

  • Afonina, I.; Cullen, S.; Martin, S.
    Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B (2010), Immunol. Rev., 235, 105-116.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Pichia pastoris Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
interleukin IL-1alpha + H2O Homo sapiens cleavage after the motif IAND103, no substrate for caspases -1, -3, -4, -5, and -7 ? granzyme B-mediated processing of IL-1alpha potently enhances the biological activity ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
interleukin IL-1alpha + H2O cleavage after the motif IAND103, no substrate for caspases -1, -3, -4, -5, and -7 Homo sapiens ? granzyme B-mediated processing of IL-1alpha potently enhances the biological activity ?
additional information no substrate: interleukin IL-1beta Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Gzm B
-
Homo sapiens

General Information

General Information Comment Organism
physiological function granzyme B-mediated processing of IL-1alpha potently enhances the biological activity. Granzyme B does not directly influence inflammatory cytokine production by HeLa or HUVEC cells Homo sapiens