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Literature summary for 3.4.21.79 extracted from
- Activated T-cells inhibit neurogenesis by releasing granzyme B: rescue by Kv1.3 blockers (2010), J. Neurosci., 30, 5020-5027.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| T-lymphocyte | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| granzyme B | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the effect of T-cell activation on neural progenitor cell (NPC) functions: NPC proliferation and neuronal differentiation are impaired by granzyme B released by the T-cells. GrB mediate its effects by the activation of a Gi-protein-coupled receptor leading to decreased intracellular levels of cAMP and subsequent expression of the voltage-dependent potassium channel, Kv1.3. Blocking channel activity with margatoxin or blocking its expression reverses the inhibitory effects of GrB on neural progenitor cells | Homo sapiens |
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Release 2023.1 (January 2023)
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