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Literature summary for 3.4.21.79 extracted from
- Delivery and therapeutic potential of human granzyme B (2010), Immunol. Rev., 235, 159-171.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | modified versions of GzmB with lower isoelectric points can be utilized without loss of apoptosis-inducing potential but fewer side activities | Homo sapiens |
| medicine | since GzmB is very effective in killing human tumor cell lines that are resistant against cytotoxic drugs GrzmB is used as an effector domain in potential immunoconjugates | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in bacteria and eukaryotic cells. The large scale production of recombinant GzmB in bacteria may necessitate refolding, but this is easily achieved in optimized detergent-free refolding buffers | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| R226G | replacing Arg-226 by a glycine yields an enzyme with chymase-like activity cleaving like cathepsin G after Phe | Mus musculus |
| R226G | replacing Arg-226 by a glycine yields an enzyme with chymase-like activity cleaving like cathepsin G after Phe | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 100 kDa assembly protein (Ad5-100K) | no inhibition is seen in mouse or rat | Homo sapiens | |
| cytokine response modifier A (CrmA) of poxyvirus | virally encoded serpin | Homo sapiens | |
| proteinase inhibitor 9 (PI-9) | - |
Homo sapiens | |
| serine protease inhibitor 6 (Spi6) | - |
Mus musculus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 25000 | - |
1 * 25000 Da | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Homo sapiens |
| proteolytic modification | first expressed as an inactive proenzyme | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| natural killer cell | highly expressed | Homo sapiens | - |
| T-lymphocyte | highly expressed in CD8+ T cells | Homo sapiens | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 25000 Da | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| granzyme B | - |
Mus musculus |
| granzyme B | - |
Homo sapiens |
| GzmB | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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