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Literature summary for 3.4.21.79 extracted from
- Identification of alpha-tubulin as a granzyme B substrate during CTL-mediated apoptosis (2006), J. Cell Sci., 119, 858-865.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | role for granzyme B in the dismantling of the cytoskeleton. In the execution phase of apoptosis it may modify key structural proteins thus enabling the cell to be properly dismantled and eliminated by phagocytosis | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EGTA | inhibits granular granzyme B-mediated killing | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | YT-Indy cell line | Homo sapiens | - |
| natural killer cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-tubulin + H2O | alpha-tubulin derived from HeLa S100 extracts or Jurkat S100 extracts is cleaved by grB in a caspase-independent manner. Cleavage occurs at D438. Polymerized and soluble alpha-tubulin can be cleaved | Homo sapiens | truncated alpha-tubulin | - |
? | |
| pro-caspase-3 + H2O | - |
Homo sapiens | caspase-3 + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GrB | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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