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Literature summary for 3.4.21.79 extracted from

  • Hostetter, D.R.; Loeb, C.R.; Chu, F.; Craik, C.S.
    Hip is a pro-survival substrate of granzyme B (2007), J. Biol. Chem., 282, 27865-27874.
    View publication on PubMed

Application

Application Comment Organism
medicine GrB proteolysis of Hsc70/Hsp70-interacting protein is important to the efficiency of death induction Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Bcl-2-associated athano gene-1 + H2O GrB proteolysis is independent of caspase activity Homo sapiens ?
-
?
Hsc70/Hsp70-interacting protein + H2O Hsc70/Hsp70-interacting protein is cleaved at both GrB cleavage sites (at sequences IEPD92-TD and INPD180-SA) during NK-mediated cell death in a caspase-independent manner. Hsc70/Hsp70-interacting protein is a substrate unique to GrB Homo sapiens ?
-
?
Hsp70/Hsp90-organizing protein + H2O
-
Homo sapiens ?
-
?
Hsp90 + H2O is proteolyzed at multiple sites by GrB. Cleavage at sequences IDED693-EV and INPD631-PI in Hsp90beta. Cleavage at sequences IDED701-DP, INPD639-HS and VRTD175-TG in Hsp90alpha Homo sapiens ?
-
?
additional information Hsp27 is resistant to GrB proteolysis Homo sapiens ?
-
?
poly(ADP-ribose) polymerase + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
GrB
-
Homo sapiens