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Literature summary for 3.4.21.79 extracted from

  • Pardo, J.; Wallich, R.; Martin, P.; Urban, C.; Rongvaux, A.; Flavell, R.A.; Muellbacher, A.; Borner, C.; Simon, M.M.
    Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs (2008), Cell Death Differ., 15, 567-579.
    View publication on PubMed
Search for more literature for 3.4.21.79

Application

Application Comment Organism
medicine pleiotropic pro-apoptotic function of gzmB presumably to counteract evasion strategies of pathogens and to control tumors Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information gzmB-/-CTL cells, no cleavage of Bid Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 B6 background
-

Source Tissue

Source Tissue Comment Organism Textmining
cytotoxic T-lymphocyte cell line expresses gzmB. Positive gzmB cytotoxic T-lymphocyte cells abrogate target cell proliferation by inducing cell death, independent of caspases and mitochondrial signaling. Positive gzmB cytotoxic T-lymphocyte cells independently induce pro-apoptotic processes either via caspase-3/-7, leading to plasma membrane perturbance and ROS production or via Bid/Bak/Bax, resulting in cytochrome c release, whereby both pathways elicit loss of mitochondrial membrane potential Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
BID + H2O
-
 Mus musculus truncated BID + ?
-
 ?
pro-caspase-3 + H2O
-
 Mus musculus caspase-3 + ?
-
 ?
pro-caspase-7 + H2O
-
 Mus musculus caspase-7 + ?
-
 ?

Synonyms

Synonyms Comment Organism
GzmB
-
 Mus musculus