Application | Comment | Organism |
---|---|---|
medicine | cytolytic T-lymphocytes from enzyme or granzyme A deficient mice similarly induce early proapoptotic features such as phosphatidyl serine exposure on plasma membrane, or reactive oxygen radical generation, though with distinct kinetics. Cytolytic T-lymphocytes from granzyme A, but not granzyme B deficient animals activate caspase 3 and 9. All granzyme-induced apoptotic features depend critically on perforin | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
homozygous deficiency in enzyme | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
T-lymphocyte | - |
Mus musculus | - |