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Literature summary for 3.4.21.79 extracted from

  • Pardo, J.; Bosque, A.; Brehm, R.; Wallich, R.; Naval, J.; Mullbacher, A.; Anel, A.; Simon, M.M.
    Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis (2004), J. Cell Biol., 167, 457-468.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine cytolytic T-lymphocytes from enzyme or granzyme A deficient mice similarly induce early proapoptotic features such as phosphatidyl serine exposure on plasma membrane, or reactive oxygen radical generation, though with distinct kinetics. Cytolytic T-lymphocytes from granzyme A, but not granzyme B deficient animals activate caspase 3 and 9. All granzyme-induced apoptotic features depend critically on perforin Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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homozygous deficiency in enzyme
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Source Tissue

Source Tissue Comment Organism Textmining
T-lymphocyte
-
Mus musculus
-