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Literature summary for 3.4.21.77 extracted from

  • Saraswati, S.; Block, A.S.; Davidson, M.K.; Rank, R.G.; Mahadevan, M.; Diekman, A.B.
    Galectin-3 is a substrate for prostate specific antigen (PSA) in human seminal plasma (2011), Prostate, 71, 197-208.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Galectin-3 + H2O Homo sapiens carbohydrate-binding protein involved in cell adhesion, cell cycle control, immunomodulation, and cancer progression, including prostate cancer ? PSA cleaves galactin-3 between residues Y107 and G108 to produce an active, monovalent lectin ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
semen
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Galectin-3 + H2O carbohydrate-binding protein involved in cell adhesion, cell cycle control, immunomodulation, and cancer progression, including prostate cancer Homo sapiens ? PSA cleaves galactin-3 between residues Y107 and G108 to produce an active, monovalent lectin ?

General Information

General Information Comment Organism
physiological function PSA regulates galectin-3 in human semen and may regulate galectin-3 function during prostate cancer progression Homo sapiens