Literature summary for 3.4.21.76 extracted from

Chen, Y.; Liu, Z.; Pan, T.; Chen, E.; Mao, E.; Chen, Y.; Tan, R.; Wang, X.; Tian, R.; Liu, J.; Qu, H.
JMJD3 is involved in neutrophil membrane proteinase 3 overexpression during the hyperinflammatory response in early sepsis (2018), Int. Immunopharmacol., 59, 40-46 .

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Cloned(Commentary)

Cloned (Comment)	Organism
gene PRTN3, quantitative real-time PCR enzyme expression analysis	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P24158	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	the neutrophil membrane mPR3 is highly induced in patients with sepsis	Homo sapiens	-
neutrophil	-	Homo sapiens	-
THP-1 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
membrane proteinase 3	-	Homo sapiens
mPR3	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	histone demethylase JMJD3 (EC 1.14.11.68) regulates the expression of neutrophil membrane proteinase 3 (mPR3) in lipopolysaccharide-stimulated neutrophils during the early inflammatory response in sepsis	up

General Information

General Information	Comment	Organism
metabolism	histone demethylase JMJD3 (EC 1.14.11.68) regulates the expression of neutrophil membrane proteinase 3 (mPR3) in lipopolysaccharide-stimulated neutrophils during the early inflammatory response in sepsis. JMJD3 regulates the expression of mPR3 by changing the level of trimethylated histone H3 on Lys27 (H3K27me3) in LPS-stimulated neutrophils	Homo sapiens
physiological function	membrane proteinase 3 (mPR3) expression on neutrophils plays a critical role in pro-inflammatory cytokine production. Plasma cytokine (interleukin-1beta and TNF-alpha) levels are increased in patients with sepsis exhibiting high mPR3 expression	Homo sapiens

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Release 2023.1 (January 2023)