Literature summary for 3.4.21.76 extracted from

Hinkofer, L.C.; Hummel, A.M.; Stone, J.H.; Hoffman, G.S.; Merkel, P.A.; Spiera, E.R.; St Clair, W.; McCune, J.W.; Davis, J.C.; Specks, U.; Jenne, D.E.
Allosteric modulation of proteinase 3 activity by anti-neutrophil cytoplasmic antibodies in granulomatosis with polyangiitis (2015), J. Autoimmun., 59, 43-52.

Search for more literature for 3.4.21.76

Application

Application	Comment	Organism
diagnostics	anti-neutrophil cytoplasmic antibodies with proteinase 3 specificity are a useful laboratory biomarker for the diagnosis of granulomatosis with polyangiitis, i.e.Wegener's granulomatosis	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
alpha-1-Proteinase inhibitor	inhibits the enzyme, inhibition is implicated by anti-neutrophil cytoplasmic antibodies with proteinase 3 specificity	Homo sapiens
anti-neutrophil cytoplasmic antibodies with proteinase 3 specificity	screening: a great majority of PR3-ANCA has inhibitory capacity towards the enzyme, overview. PR3-ANCA with inhibitory properties bind to the active site surface of proteinase 3. Epitopes of inhibitory PR3-ANCA are not masked by elafin	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P24158	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-TAMRA-VADnVRDYQ-diaminopropionyl-fluorescein + H2O	fluorogenic substrate	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
PR3	-	Homo sapiens
proteinase 3	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	the enzyme is involved in granulomatosis with polyangiitis, anti-neutrophil cytoplasmic antibodies with proteinase 3 specificity are not implicated in the pathogenesis	Homo sapiens

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Release 2023.1 (January 2023)