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Literature summary for 3.4.21.76 extracted from

  • Villegas-Mendez, A.; Montes, R.; Ambrose, L.R.; Warrens, A.N.; Laffan, M.; Lane, D.A.
    Proteolysis of the endothelial cell protein C receptor by neutrophil proteinase 3 (2007), J. Thromb. Haemost., 5, 980-988.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine down-regulation of anticoagulation during inflammation by rapid endothelial cell protein C receptor proteolysis by PR3 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha1-antitrypsin
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
Homo sapiens 9986
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
more than 95% pure Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
Homo sapiens
-
neutrophil
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
endothelial cell protein C receptor + H2O PR3 produces multiple cleavages, with early products including 20 kDa N-terminal and C-terminal (after Lys176) fragments. High affinity interaction between PR3 and the endothelial cell protein C receptor (KD of 18.5–102 nanomol) Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
neutrophil protease PR3
-
Homo sapiens
PR3
-
Homo sapiens
proteinase 3
-
Homo sapiens
surface proteinase 3
-
Homo sapiens