Application | Comment | Organism |
---|---|---|
medicine | down-regulation of anticoagulation during inflammation by rapid endothelial cell protein C receptor proteolysis by PR3 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha1-antitrypsin | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
more than 95% pure | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukocyte | - |
Homo sapiens | - |
neutrophil | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
endothelial cell protein C receptor + H2O | PR3 produces multiple cleavages, with early products including 20 kDa N-terminal and C-terminal (after Lys176) fragments. High affinity interaction between PR3 and the endothelial cell protein C receptor (KD of 18.5102 nanomol) | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
neutrophil protease PR3 | - |
Homo sapiens |
PR3 | - |
Homo sapiens |
proteinase 3 | - |
Homo sapiens |
surface proteinase 3 | - |
Homo sapiens |