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Literature summary for 3.4.21.76 extracted from

  • Korkmaz, B.; Hajjar, E.; Kalupov, T.; Reuter, N.; Brillard-Bourdet, M.; Moreau, T.; Juliano, L.; Gauthier, F.
    Influence of charge distribution at the active site surface on the substrate specificity of human neutrophil protease 3 and elastase. A kinetic and molecular modeling analysis (2007), J. Biol. Chem., 282, 1989-1997.
    View publication on PubMed
Search for more literature for 3.4.21.76

Application

Application Comment Organism
drug development optimized sequences, which allow close interaction with the extended active site of Pr3 for the development of peptide or pseudopeptide inhibitors that do not interfere with Pr3-related proteases Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1
-
 Abz-VADCADRQ-EDDnp
-
 Homo sapiens
3.3
-
 Abz-VADCRDRQ-EDDnp
-
 Homo sapiens
6.5
-
 2-aminobenzoyl-VADCADQ-EDDnp
-
 Homo sapiens
12
-
 Abz-VADCDDRQ-EDDnp
-
 Homo sapiens
12.3
-
 2-aminobenzoyl-VADCAQ-EDDnp
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-GIATDCRDRPEQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-GIATFCDLMPEQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-GIATFCMKMPEQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-GIATFCMLMPEQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-GIATFCRLMPEQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-GRATFCMLMPEQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-VADCADQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-VADCADQ-ethylene diamine 2,4 dinitrophenyl + H2O
-
 Homo sapiens ?
-
 ?
Abz-VADCADRQ-EDDnp + H2O
-
 Homo sapiens Abz-VADCA + DRQ-EDDnp
-
 ?
Abz-VADCAQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-VADCDDRQ-EDDnp + H2O
-
 Homo sapiens Abz-VADCD + DRQ-EDDnp
-
 ?
Abz-VADCRDRQ-EDDnp + H2O
-
 Homo sapiens Abz-VADCR + DRQ-EDDnp
-
 ?
Abz-VADnVADRQ-EDDnp + H2O
-
 Homo sapiens Abz-VADnVA + DRQ-EDDnp
-
 ?
Abz-VADnVADYQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-VADnVRDRQ-EDDnp + H2O
-
 Homo sapiens Abz-VADnVR + DRQ-EDDnp
-
 ?
Abz-VADnVRDYQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
Abz-VADVKDRQ-EDDnp + H2O
-
 Homo sapiens Abz-VADVK + DRQ-EDDnp
-
 ?
Abz-VARCRDRQ-EDDnp + H2O
-
 Homo sapiens Abz-VARCR + DRQ-EDDnp
-
 ?
additional information Asp-61, Lys-99, and Arg-143 in Pr3 are in the vicinity of the substrate binding site that extends from at least subsites S4 to S3'. Subsites S1' to S3' are all in the vicinity of charged residues. Ionic interactions involving residue P3' and Asp-61 are not essential for substrate binding but elongation of the peptide chain helps to stabilize the substrate, improving catalytic efficiency Homo sapiens ?
-
 ?
NFkappaB + H2O
-
 Homo sapiens ?
-
 ?
p21 + H2O
-
 Homo sapiens ?
-
 ?
pro-TNFalpha + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PR3
-
 Homo sapiens
protease 3
-
 Homo sapiens