Application | Comment | Organism |
---|---|---|
drug development | optimized sequences, which allow close interaction with the extended active site of Pr3 for the development of peptide or pseudopeptide inhibitors that do not interfere with Pr3-related proteases | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
3.1 | - |
Abz-VADCADRQ-EDDnp | - |
Homo sapiens | |
3.3 | - |
Abz-VADCRDRQ-EDDnp | - |
Homo sapiens | |
6.5 | - |
2-aminobenzoyl-VADCADQ-EDDnp | - |
Homo sapiens | |
12 | - |
Abz-VADCDDRQ-EDDnp | - |
Homo sapiens | |
12.3 | - |
2-aminobenzoyl-VADCAQ-EDDnp | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Abz-GIATDCRDRPEQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
Abz-GIATFCDLMPEQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
Abz-GIATFCMKMPEQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
Abz-GIATFCMLMPEQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
Abz-GIATFCRLMPEQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
Abz-GRATFCMLMPEQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
Abz-VADCADQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
Abz-VADCADQ-ethylene diamine 2,4 dinitrophenyl + H2O | - |
Homo sapiens | ? | - |
? | |
Abz-VADCADRQ-EDDnp + H2O | - |
Homo sapiens | Abz-VADCA + DRQ-EDDnp | - |
? | |
Abz-VADCAQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
Abz-VADCDDRQ-EDDnp + H2O | - |
Homo sapiens | Abz-VADCD + DRQ-EDDnp | - |
? | |
Abz-VADCRDRQ-EDDnp + H2O | - |
Homo sapiens | Abz-VADCR + DRQ-EDDnp | - |
? | |
Abz-VADnVADRQ-EDDnp + H2O | - |
Homo sapiens | Abz-VADnVA + DRQ-EDDnp | - |
? | |
Abz-VADnVADYQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
Abz-VADnVRDRQ-EDDnp + H2O | - |
Homo sapiens | Abz-VADnVR + DRQ-EDDnp | - |
? | |
Abz-VADnVRDYQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
Abz-VADVKDRQ-EDDnp + H2O | - |
Homo sapiens | Abz-VADVK + DRQ-EDDnp | - |
? | |
Abz-VARCRDRQ-EDDnp + H2O | - |
Homo sapiens | Abz-VARCR + DRQ-EDDnp | - |
? | |
additional information | Asp-61, Lys-99, and Arg-143 in Pr3 are in the vicinity of the substrate binding site that extends from at least subsites S4 to S3'. Subsites S1' to S3' are all in the vicinity of charged residues. Ionic interactions involving residue P3' and Asp-61 are not essential for substrate binding but elongation of the peptide chain helps to stabilize the substrate, improving catalytic efficiency | Homo sapiens | ? | - |
? | |
NFkappaB + H2O | - |
Homo sapiens | ? | - |
? | |
p21 + H2O | - |
Homo sapiens | ? | - |
? | |
pro-TNFalpha + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PR3 | - |
Homo sapiens |
protease 3 | - |
Homo sapiens |