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Literature summary for 3.4.21.76 extracted from

  • Novick, D.; Rubinstein, M.; Azam, T.; Rabinkov, A.; Dinarello, C.A.; Kim, S.H.
    Proteinase 3 is an IL-32 binding protein (2006), Proc. Natl. Acad. Sci. USA, 103, 3316-3321.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.76

Application

Application Comment Organism
medicine specific inhibition of PR3 activity to process IL-32 or neutralization of IL-32 by inactive PR3 or its fragments may reduce the consequences of IL-32 in immune regulated diseases Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
PMSF inhibits activity, binding of IL-32 to PR3 is not inhibited Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-
soluble
-
 Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
 x * 30000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P24158
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information neutrophil-dereived PR3 is more potent than urinary PR3 Homo sapiens
-
neutrophil
-
 Homo sapiens
-
urine
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IL-32 + H2O 37°C Homo sapiens ?
-
 ?
additional information no cleavage of IFN-alpha2 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 30000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
PR3
-
 Homo sapiens
proteinase 3
-
 Homo sapiens