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Literature summary for 3.4.21.76 extracted from
- Myeloblastin: leukocyte proteinase 3 (1994), Methods Enzymol., 244, 61-67.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Alpha1-proteinase inhibitor | - |
Homo sapiens | |
| alpha2-Macroglobulin | - |
Homo sapiens | |
| Chloromethylketones | - |
Homo sapiens |  |
| DFP | - |
Homo sapiens | |
| Eglin c | weak | Homo sapiens | |
| elafin | - |
Homo sapiens | |
| additional information | aprotinin; cysteine, aspartic, or metalloproteinase inhibitors; secretory leukocyte proteinase inhibitor | Homo sapiens | |
| PMSF | - |
Homo sapiens | |
| Soybean trypsin inhibitor | - |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 29000 | - |
x * 29000, human, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | involved in control of growth and differentiation of human leukemia cells, potent microbicidal activity, is the target antigen of cytoplasmic-staining antineutrophil cytoplasmic autoantibodies circulating in Wegener's granulomatosis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | leukocyte concentrate prepared from pooled normal human blood | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| azocasein + H2O | - |
Homo sapiens | fragments of azocasein | - |
? | |
| Collagen type IV + H2O | no or minimal activity against interstitial collagens type I and III | Homo sapiens | Hydrolyzed collagen type IV | - |
? | |
| Fibronectin + H2O | - |
Homo sapiens | Hydrolyzed fibronectin | - |
? | |
| Hemoglobin + H2O | - |
Homo sapiens | Hydrolyzed hemoglobin | - |
? | |
| laminin + H2O | - |
Homo sapiens | fragments of laminin | - |
? | |
| additional information | involved in control of growth and differentiation of human leukemia cells, potent microbicidal activity, is the target antigen of cytoplasmic-staining antineutrophil cytoplasmic autoantibodies circulating in Wegener's granulomatosis | Homo sapiens | ? | - |
? | |
| Vitronectin + H2O | - |
Homo sapiens | Hydrolyzed vitronectin | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 29000, human, SDS-PAGE | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
pI: 9.1 | Homo sapiens |
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Release 2023.1 (January 2023)
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