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Literature summary for 3.4.21.76 extracted from
- Substrate and inhibitor studies on proteinase 3 (1992), FEBS Lett., 297, 119-123.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3,4-dichloroisocoumarin | - |
Homo sapiens |  |
| 7-Amino-4-chloro-3-(2-bromoethoxy)isocoumarin | - |
Homo sapiens | |
| additional information | substituted isocoumarins, peptide-phosphonates and chloromethyl ketones inhibit proteinase 3 less potently than human neutrophil elastase, by 1-2 orders of magnitude | Homo sapiens | |
| Substituted isocoumarins | - |
Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.028 | - |
tert-butyloxycarbonyl-Ala-Ala-Val-thiobenzyl ester | - |
Homo sapiens | |
| 0.031 | - |
tert-butyloxycarbonyl-Ala-Ala-Ile-thiobenzyl ester | - |
Homo sapiens | |
| 0.061 | - |
tert-butyloxycarbonyl-Ala-Ala-Met-thiobenzyl ester | - |
Homo sapiens | |
| 0.063 | - |
tert-butyloxycarbonyl-Ala-Ala-norvaline-thiobenzyl ester | - |
Homo sapiens | |
| 0.106 | - |
tert-butyloxycarbonyl-Ala-Ala-Ala-thiobenzyl ester | - |
Homo sapiens | |
| 0.148 | - |
succinyl-Ala-Ala-norvaline-thiobenzyl ester | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
healthy | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
assay methods | Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Succinyl-Ala-Ala-norvaline thiobenzyl ester + H2O | - |
Homo sapiens | ? | - |
? | |
| Tert-Butyloxycarbonyl-Ala-Ala-Ala thiobenzyl ester + H2O | - |
Homo sapiens | ? | - |
? | |
| Tert-Butyloxycarbonyl-Ala-Ala-Ile thiobenzyl ester + H2O | - |
Homo sapiens | ? | - |
? | |
| Tert-Butyloxycarbonyl-Ala-Ala-Met thiobenzyl ester + H2O | - |
Homo sapiens | ? | - |
? | |
| Tert-Butyloxycarbonyl-Ala-Ala-norvaline thiobenzyl ester + H2O | best substrate | Homo sapiens | ? | - |
? | |
| Tert-Butyloxycarbonyl-Ala-Ala-Val thiobenzyl ester + H2O | - |
Homo sapiens | ? | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.9 | - |
tert-butyloxycarbonyl-Ala-Ala-Ile thiobenzyl ester | - |
Homo sapiens | |
| 10.1 | - |
tert-butyloxycarbonyl-Ala-Ala-Ala thiobenzyl ester | - |
Homo sapiens | |
| 10.4 | - |
tert-butyloxycarbonyl-Ala-Ala-Val thiobenzyl ester | - |
Homo sapiens | |
| 12.2 | - |
tert-butyloxycarbonyl-Ala-Ala-Met thiobenzyl ester | - |
Homo sapiens | |
| 19 | - |
Succinyl-Ala-Ala-norvaline thiobenzyl ester | - |
Homo sapiens | |
| 63.3 | - |
tert-butyloxycarbonyl-Ala-Ala-norvaline thiobenzyl ester | - |
Homo sapiens | |
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