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Literature summary for 3.4.21.75 extracted from

  • Hajdin, K.; DAlessandro, V.; Niggli, F.K.; Schaefer, B.W.; Bernasconi, M.
    Furin targeted drug delivery for treatment of rhabdomyosarcoma in a mouse model (2010), PLoS ONE, 5, e10445.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine furin expression is detected in all rhabdomyosarcoma cell lines tested at high levels, while myoblasts and fibroblasts show low levels of furin transcripts. Peptide CMGTINTRTKKC has strong affinity for rhabdomyosarcoma cells in vitro and in vivo, by binding to furin Homo sapiens
medicine peptide CMGTINTRTKKC has strong affinity for rhabdomyosarcoma cells in vitro and in vivo, by binding to furin. Treatment of rhabdomyosarcoma cells in mice with doxorubicin coupled to the targeting peptide results in a two-fold increase in therapeutic efficacy compared to doxorubicin treatment alone. Surface-furin binding may be used as novel mechanism for therapeutic cell penetration Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MDA-MB-231 cell
-
 Homo sapiens
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RD cell
-
 Homo sapiens
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Rh-30 cell
-
 Homo sapiens
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Rh-4 cell
-
 Homo sapiens
-

Expression

Organism Comment Expression
Homo sapiens furin expression is detected in all rhabdomyosarcoma cell lines tested at high levels, while myoblasts and fibroblasts show low levels of furin transcripts additional information