Literature summary for 3.4.21.75 extracted from

Wang, F.; Ren, J.; Qiu, X.C.; Wang, L.F.; Zhu, Q.; Zhang, Y.Q.; Huan, Y.; Meng, Y.L.; Yao, L.B.; Chen, S.Y.; Xu, Y.M.; Yang, A.G.
Selective cytotoxicity to HER2-positive tumor cells by a recombinant e23sFv-TD-tBID protein containing a furin cleavage sequence (2010), Clin. Cancer Res., 16, 2284-2294.

Search for more literature for 3.4.21.75

Application

Application	Comment	Organism
pharmacology	development of an immunoproapoptotic molecule with antitumor activity: Her2-antigen e23sFv-TD-tBID with a 10-amino acid residue furin cleavage sequence. e23sFv-TD-tBID shows therapeutic value to humans by its cytotoxic effects on primary patient-derived breast tumor cells but not on endothelial cells. It also shows in vivo antitumor activity in female BALB/c athymic mice, overview	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression of Her2-antigen e23sFv-TD-tBID in Escherichia coli strain M15	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of an immunoproapoptotic molecule with antitumor activity: Her2-antigen e23sFv-TD-tBID with a 10-amino acid residue furin cleavage sequence. Purified e23sFv-TD-tBID protein recognized breast cancer cells from patients and preserved the ability to kill HER2-positive tumor cells after incubation in human serum	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant Her2-antigen e23sFv-TD-tBID from Escherichia coli strain M15	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
MDA-MB-453 cell	-	Homo sapiens	-
ovary cancer cell	-	Homo sapiens	-
SK-BR-3 cell	-	Homo sapiens	-
SKOV-3 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)