Literature summary for 3.4.21.75 extracted from

Nagamine, S.; Keino-Masu, K.; Shiomi, K.; Masu, M.
Proteolytic cleavage of the rat heparan sulfate 6-O-endosulfatase SulfFP2 by furin-type proprotein convertases (2010), Biochem. Biophys. Res. Commun., 391, 107-112.

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Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
heparan sulfate 6-O-endosufatase Sulf2 + H2O	cleavage at arginine 570, located in the consensus sequence for the cleavage by furin-type proprotein convertases. The consensus sequence of the cleavage by furin and PCs is R/K-X-R/K-X-R/K-R-/-X. R, K, X, and denote arginine, lysine, any amino acid. Proteolytic processing of SulfFP2 protein by furin and furin-like proprotein convertases, and activity with Sulf2 truncation and exchange mutants, overview	Rattus norvegicus	?	-	?

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Release 2023.1 (January 2023)