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Literature summary for 3.4.21.75 extracted from

  • Coppola, J.M.; Bhojani, M.S.; Ross, B.D.; Rehemtulla, A.
    A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness (2008), Neoplasia, 10, 363-370.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.75

Inhibitors

Inhibitors Comment Organism Structure
decanoyl-Arg-Val-Lys-Arg-chloromethylketone 20 micromol results in a decrease in processed sol-membrane type-1 matrix metalloproteinase, significant decrease in motility compared to control cells Cricetulus griseus
additional information cell-permeable, small-molecule compound, which inhibits at 15 micromol furin-mediated cleavage of pro-membrane type-1 matrix metalloproteinase, resulting in an almost complete inhibition of matrix metalloprotease-2-related cell motility in CHO cells Cricetulus griseus
additional information cell-permeable, small-molecule compound, which inhibits furin-mediated cleavage of pro-membrane type-1 matrix metalloproteinase, resulting in a 50% decrease in the invasiveness of the HT1080 cell Homo sapiens

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CHO cell
-
 Cricetulus griseus
-
HT-1080 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
membrane type-1 matrix metalloproteinase + H2O
-
 Cricetulus griseus ?
-
 ?
membrane type-1 matrix metalloproteinase + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Proprotein convertase
-
 Cricetulus griseus
Proprotein convertase
-
 Homo sapiens