Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Tumor necrosis factor alpha | - |
Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | pivotal role for furin, MT1-MMP, and MMP2 in tumor necrosis factor alpha-induced sphingolipid signaling. This system may be a possible target to inhibit smooth muscle cell proliferation in vascular diseases | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha1-PDX inhibitor | - |
Homo sapiens | |
brefeldin A | blocks the tumor necrosis factor alpha-induced activation of furin and subsequent neutral sphingomyelinase activation, without altering the basal level of furin | Homo sapiens | |
decanoyl-Arg-Val-Lys-Arg-chloromethylketone | - |
Homo sapiens | |
monensin | blocks the tumor necrosis factor alpha-induced activation of furin and subsequent neutral sphingomyelinase activation, without altering the basal level of furin | Homo sapiens | |
siRNA | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
smooth muscle cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
inactive pro-MT1-MMP + H2O | - |
Homo sapiens | active MT1-MMP + ? | - |
? | |
pyroglutamic acid-Arg-Thr-Lys-Arg-methylcoumaryl-7-amide + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
proconvertase | - |
Homo sapiens |