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Literature summary for 3.4.21.75 extracted from

  • Pasquato, A.; Seidah, N.G.
    The H5N1 influenza variant Fujian-like hemagglutinin selected following vaccination exhibits a compromised furin cleavage: Neurological consequences of highly pathogenic Fujian H5N1 strains (2008), J. Mol. Neurosci., 35, 339-343.
    View publication on PubMed
Search for more literature for 3.4.21.75

Activating Compound

Activating Compound Comment Organism Structure
heparin optimizies furin processing of substrates containing multibasic residues at strategic P-positions within the cleavage site. Incubation of Fujian-like peptides with heparin results in ca. 2- to 3fold enhancement of processing. Heparin at a concentration of 0.02 mM dramatically enhances processing of the basic highly pathogenic Queretaro H5N2 peptide, albeit at neutral pH. It has no effect on processing of low pathogenic Mexico H5N2 peptide Homo sapiens

Application

Application Comment Organism
medicine massive vaccination of host poultry results in an influenza variant Fujian-like H5N1 strain with two mutations at the furin-processing site of hemagglutinin, which is resistant to immunization Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
highly pathogenic Queretaro H5N2 hemagglutinin + H2O only processed in the presence of heparin Homo sapiens ?
-
 ?
influenza deltaK-Fujian-like H5N1 hemagglutinin + H2O 76% processed Homo sapiens ?
-
 ?
influenza Fujian-like H5N1 hemagglutinin + H2O 70% processed Homo sapiens ?
-
 ?
influenza variant Fujian-like H5N1 hemagglutinin + H2O mutations at the furin-processing site of the hemagglutinin, is less cleaved (38%) by furin as compared to the parent Fujian-like strain derived peptides Homo sapiens ?
-
 ?
additional information low pathogenic Mexico H5N2 hemagglutinin is not processed by furin Homo sapiens ?
-
 ?
Pyr-Arg-Thr-Lys-Arg-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Proprotein convertase
-
 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6 7.5 influenza deltaK-Fujian-like H5N1 peptide is the best furin substrate between pH 6-7.5. At pH 6, all Fujian-like peptides are cleaved with lower kinetics as compared to pH 7.5. Low pathogenic Mexico H5N2 peptide and highly pathogenic Queretaro H5N2 peptide are not processed by furin at either pH 7.5 or 6 Homo sapiens