Literature summary for 3.4.21.75 extracted from

Pasquato, A.; Dettin, M.; Basak, A.; Gambaretto, R.; Tonin, L.; Seidah, N.G.; Di Bello, C.
Heparin enhances the furin cleavage of HIV-1 gp160 peptides (2007), FEBS Lett., 581, 5807-5813.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	heparin-peptide interaction may better expose site1, and hence allow more effective furin cleavage. Extended sequences require heparin for optimal processing by furin	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
BSC40 cells infected with soluble furin	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
HIV-1 gp160 + H2O	13mer and 19mer peptides digested equally well by furin at site1, showing complete processing at 5 h. 41mer and 51mer peptides are either barely or unprocessed, respectively. Product inhibition does not explain inability of furin to process the 41mer and 51mer peptides. Extended sequences require heparin for optimal processing	Homo sapiens	?	-	?
pyroglutamic acid-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
Proprotein convertase	-	Homo sapiens

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Release 2023.1 (January 2023)