Application | Comment | Organism |
---|---|---|
additional information | furin A activates endothelin 1 signaling | Danio rerio |
additional information | furin B activates endothelin 1 signaling | Danio rerio |
Protein Variants | Comment | Organism |
---|---|---|
additional information | loss of furin A function causes only a partial loss of endothelin 1 function. Furin A mutants typically have wild-type looking anterior arch ventral cartilages that are abnormally fused to dorsal cartilages. Cartilages of the posterior arches are also typically wild type, with a low penetrance of cartilage reduction observed in the third and fourth arches. Shape changes and bony fusions between the opercle and posterior branchiostegal ray, and altered muscle insertion points near joint domains. Arches fail to correctly undergo ventral elongation before skeletogenesis begins. Furin A mutants have defects in intermediate domain elements of the pharyngeal skeleton and mildly ruffled fins. Expression of endothelin 1-dependent genes is downregulated. Later in development, expression of most of these genes recovers to near wild-type levels | Danio rerio |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | Q1KHF8 | - |
- |
Danio rerio | Q1KHF9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Danio rerio | - |
Synonyms | Comment | Organism |
---|---|---|
furin A | - |
Danio rerio |
furin B | - |
Danio rerio |