Literature summary for 3.4.21.75 extracted from

Silvestri, L.; Pagani, A.; Camaschella, C.
Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis (2008), Blood, 111, 924-931.

Search for more literature for 3.4.21.75

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	furin is up-regulated by iron deficiency and hypoxia in association with the stabilization of HIF-1alpha	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
R335Q	cleavage mutant, soluble hemojuvelin is reduced	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	soluble hemojuvelin is reduced in cells treated with a furin inhibitor	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	soluble hemojuvelin originates from a furin cleavage at position 332-335. Soluble hemojuvelin is increased in cells overexpressing exogenous furin	Mus musculus	?	-	?

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Release 2023.1 (January 2023)