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Literature summary for 3.4.21.75 extracted from

  • Kurmanova, A.; Llorente, A.; Polesskaya, A.; Garred, O.; Olsnes, S.; Kozlov, J.; Sandvig, K.
    Structural requirements for furin-induced cleavage and activation of Shiga toxin (2007), Biochem. Biophys. Res. Commun., 357, 144-149.
    View publication on PubMed
Search for more literature for 3.4.21.75

Cloned(Commentary)

Cloned (Comment) Organism
stably transfected LoVo cells expressing either furin (LoVo/fur) or the vector alone (LoVo/neo) Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information LoVo/neo cells lacking functional furin are unable to activate both wild type Shiga toxin and mutant Shiga-2D toxin Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
HEp-2 cell
-
 Homo sapiens
-
LoVo cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information is not able to cleave mutant Shiga-2D toxin Mus musculus ?
-
 ?
additional information is not able to cleave mutant Shiga-2D toxin Homo sapiens ?
-
 ?
Shiga toxin + H2O not only the sequence known to be a minimal furin-recognition site, but also the structure around this site are important for furin processing of Shiga toxin and for rapid intoxication Mus musculus ?
-
 ?
Shiga toxin + H2O not only the sequence known to be a minimal furin-recognition site, but also the structure around this site are important for furin processing of Shiga toxin and for rapid intoxication Homo sapiens ?
-
 ?