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Literature summary for 3.4.21.75 extracted from
- Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition (2006), Am. J. Physiol. Renal Physiol., 290, F1488-1496.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Xenopus laevis | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| oocyte | - |
Xenopus laevis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| epithelial Na+ channel + H2O | furin cleavage of epithelial Na+ channel subunits activates the channels by relieving Na+ self-inhibition. Activation requires that the alpha-subunit is cleaved twice | Xenopus laevis | ? | - |
? |  |
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