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Literature summary for 3.4.21.75 extracted from

  • Krysan, D.J.; Rockwell, N.C.; Fuller, R.S.
    Quantitative characterization of furin specificity. Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methylcoumarinamides (1999), J. Biol. Chem., 274, 23229-23234.
    View publication on PubMed
Search for more literature for 3.4.21.75

Inhibitors

Inhibitors Comment Organism Structure
additional information Boc-RVRR-4-methylcoumarin-7-amide does not show any signs of substrate inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0006
-
 AcRYRFKR-4-methylcoumarin-7-amide pH 7.0, 37°C Homo sapiens
0.0008
-
 AcRYKR-4-methylcoumarin-7-amide pH 7.0, 37°C Homo sapiens
0.0009
-
 AcRARYKR-4-methylcoumarin-7-amide pH 7.0, 37°C Homo sapiens
0.001
-
 acetyl-norleucineYKR-7-amido-4-methylcoumarin pH 7.0, 37°C Homo sapiens
0.019
-
 Boc-RVRR-4-methylcoumarin-7-amide pH 7.0, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus trans Golgi network Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens implicated in maturation of substrates involved in development, signaling, coagulation, and pathogenesis, constitutive secretory pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ac-AAKYKR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-AAKYKR
-
 ?
Ac-AARYKR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-AARYKR
-
 ?
Ac-KARYKR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-KARYKR
-
 ?
Ac-norleucine-YKR-4-methylcoumarin-7-amide
-
 Homo sapiens acetyl-norleucine-YKR + 7-amino-4-methylcoumarin
-
 ?
Ac-RA-norvaline-YKR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-RA-norvaline-YKR
-
 ?
Ac-RAKYKR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-RAKYKR
-
 ?
Ac-RARYAR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-RARYAR
-
 ?
Ac-RARYKR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-RARYKR
-
 ?
Ac-RARYRR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-RARYRR
-
 ?
Ac-RYKR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-RYRR
-
 ?
Ac-RYRFKR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-RYRFKR
-
 ?
acetyl-norleucine-YKR-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens acetyl-norleucine-YKR + 7-amino-4-methylcoumarin
-
 ?
AcRARYKK-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + AcRARYKK
-
 ?
Boc-RVRR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Boc-RVRR
-
 ?
additional information implicated in maturation of substrates involved in development, signaling, coagulation, and pathogenesis, constitutive secretory pathway Homo sapiens ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
21
-
 Boc-RVRR-4-methylcoumarin-7-amide pH 7.0, 37°C Homo sapiens
50
-
 acetyl-norleucine-YKR-7-amido-4-methylcoumarin pH 7.0, 37°C Homo sapiens
193
-
 AcRYKR-4-methylcoumarin-7-amide pH 7.0, 37°C Homo sapiens
200
-
 AcRYRFKR-4-methylcoumarin-7-amide pH 7.0, 37°C Homo sapiens
250
-
 AcRARYKR-4-methylcoumarin-7-amide pH 7.0, 37°C Homo sapiens