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Literature summary for 3.4.21.75 extracted from
- Synthetic peptides derived from the prosegments of proprotein convertase 1/3 and furin are potent inhibitors of both enzymes (2003), Biochem. J., 373, 231-239.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| recombinant hfurin from the sectreted culture media of somatomammotroph GH4C1 cells following infection with respective cDNA encoding vaccinia viruses | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| profurin 39-62 DYYHFWHRGVKRSLSPHRPRHSR | - |
Homo sapiens |  |
| profurin 48-62 VTKRSLSPHRPRHSR | peptide derived from proprotein convertase 1/3 | Homo sapiens | |
| profurin 54-62 SPHRPRHSR | peptide derived from proprotein convertase 1/3 | Homo sapiens | |
| proPC1/3 39-62 NHYLFKHKSHPRRSALAITKR | peptide derived from proprotein convertase 1/3 | Homo sapiens | |
| proPC1/3 39-62/A NAYLF KAKSAPRRSRRSALAITKR | peptide derived from proprotein convertase 1/3 | Homo sapiens | |
| proPC1/3 50-62 RRSRR SALHITKR | peptide derived from proprotein convertase 1/3 | Homo sapiens | |
| proPC1/3 50-83 RRSRRSALHITKRLSDDDRVTWAEQQYEKERSKR | peptide derived from proprotein convertase 1/3 | Homo sapiens | |
| proPC1/3 55-62 SALHITKR | peptide derived from proprotein convertase 1/3 | Homo sapiens | |
| proPC1/3 55-62/A SALAITKR | peptide derived from proprotein convertase 1/3 | Homo sapiens | |
| proPC1/3 74-83 QQYEKERSKR | peptide derived from proprotein convertase 1/3 | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially, recombinant hfurin | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| p-Glu-Arg-Thr-Lys-Arg-4-methylcoumaryl-7-amide + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| hfurin | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0007 | - |
proPC1/3 39-62 NHYLF KHKSHPRRSALAITKR | pH7.0, 25°C | Homo sapiens | |
| 0.0009 | - |
profurin 39-62 DYYHFWHRGVKRSLSPHRPRHSR | pH 7.0, 25°C | Homo sapiens | |
| 0.0012 | - |
proPC1/3 39-62/A NAYLF KAKSAPRRSRRSALAITKR | pH 7.0, 25°C | Homo sapiens | |
| 0.0023 | - |
proPC1/3 50-62 RRSRR SALHITKR | pH 7.0, 25°C | Homo sapiens | |
| 0.0028 | - |
profurin 48-62 VTKRSLSPHRPRHSR | pH 7.0, 25°C | Homo sapiens | |
| 0.0048 | - |
proPC1/3 50-83 RRSRRSALHITKRLSDDDRVTWAEQQYEKERSKR | pH 7.0, 25°C | Homo sapiens | |
| 0.013 | - |
proPC1/3 55-62/A SALAITKR | pH 7.0, 25°C | Homo sapiens | |
| 0.0154 | - |
proPC1/3 39-62 NHYLF KHKSHPRRSALAITKR | pH 7.0, 25°C | Homo sapiens | |
| 0.023 | - |
profurin 54-62 SPHRPRHSR | pH 7.0, 25°C | Homo sapiens | |
| 0.0316 | - |
proPC1/3 55-62 SALHITKR | pH 7.0, 25°C | Homo sapiens | |
| 0.0475 | - |
proPC1/3 74-83 QQYEKERSKR | pH 7.0, 25°C, competitive inhibition | Homo sapiens | |
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