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Literature summary for 3.4.21.75 extracted from

  • Jean, F.; Basak, A.; DiMaio, J.; Seidah, N.G.; Lazure, C.
    An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor (1995), Biochem. J., 307, 689-695.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
additional information a potent inhibitor containing a ketomethylene arginyl pseudopeptide bond; contains Cys near the active site His Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0059
-
 Glu-Arg-Thr-Lys-Arg-(7-methylcoumarin-4-yl)acetate
-
 Homo sapiens
0.03
-
 (2-Aminobenzoyl)-Lys-Glu-Arg-Ser-Lys-Arg-Ser-Ala-Leu-Arg-Asp-(3-nitro)Tyr-Ala
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2-Aminobenzoyl)-Lys-Glu-Arg-Ser-Lys-Arg-Ser-Ala-Leu-Arg-Asp-(3-nitro)Tyr-Ala + H2O
-
 Homo sapiens (2-Aminobenzoyl)-Lys-Glu-Arg-Ser-Lys-Arg + Ser-Ala-Leu-Arg-Asp-(3-nitro)Tyr-Ala
-
 ?
Glu-Arg-Thr-Lys-Arg-(7-methylcoumarin-4-yl)acetate + H2O
-
 Homo sapiens Glu-Arg-Thr-Lys-Arg + (7-methylcoumarin-4-yl)acetate
-
 ?
pGlu-Arg-Thr-Lys-Arg-(7-methylcoumarin-4-yl)acetate + H2O
-
 Homo sapiens ?
-
 ?