Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.75 extracted from

  • Jean, F.; Boudreault, A.; Basak, A.; Seidah, N.G.; Lazure, C.
    Fluorescent peptidyl substrates as an aid in studying the substrate specificity of human prohormone convertase PC1 and human furin and designing a potent irreversible inhibitor (1995), J. Biol. Chem., 270, 19225-19231.
    View publication on PubMed
Search for more literature for 3.4.21.75

Inhibitors

Inhibitors Comment Organism Structure
Octapeptidyl chloromethane inhibitor potent irreversible inhibitor Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens
0.0015
-
 Acetyl-Arg-Pro-Lys-Arg-4-methylcoumarin 7-amide
-
 Homo sapiens
0.005
-
 Acetyl-Arg-Ser-Lys-Arg-4-methylcoumarin 7-amide
-
 Homo sapiens
0.0071
-
 Acetyl-Tyr-Glu-Lys-Glu-Arg-Ser-Lys-Arg-4-methylcoumarin 7-amide
-
 Homo sapiens
0.008
-
 Acetyl-Arg-Lys-Lys-Arg-4-methylcoumarin 7-amide
-
 Homo sapiens
0.016
-
 Acetyl-Arg-Glu-Lys-Arg-4-methylcoumarin 7-amide
-
 Homo sapiens
0.028
-
 Acetyl-Orn-Ser-Lys-Arg-4-methylcoumarin 7-amide
-
 Homo sapiens
0.106
-
 Acetyl-Lys-Ser-Lys-Arg-4-methylcoumarin 7-amide
-
 Homo sapiens
0.345
-
 Acetyl-Arg-Phe-Ala-Arg-4-methylcoumarin 7-amide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Acetyl-Arg-Glu-Lys-Arg-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
Acetyl-Arg-Lys-Lys-Arg-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
Acetyl-Arg-Phe-Ala-Arg-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
Acetyl-Arg-Pro-Lys-Arg-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
Acetyl-Arg-Ser-Lys-Arg-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
Acetyl-Lys-Ser-Lys-Arg-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
Acetyl-Orn-Ser-Lys-Arg-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
Acetyl-Phe-Ala-Arg-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
acetyl-Tyr-Glu-Lys-Glu-Arg-Ser-Lys-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens acetyl-Tyr-Glu-Lys-Glu-Arg + Ser-Lys-7-amido-4-methylcoumarin
-
 ?
Acetyl-Tyr-Glu-Lys-Glu-Arg-Ser-Lys-Arg-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
additional information study of the specificity of human prohormone convertase PC1 and human furin Homo sapiens ?
-
 ?
Pyr-Arg-Thr-Lys-Arg-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens
0.00088
-
 Acetyl-Orn-Ser-Lys-Arg-4-methylcoumarin 7-amide
-
 Homo sapiens
0.000934
-
 Acetyl-Arg-Glu-Lys-Arg-4-methylcoumarin 7-amide
-
 Homo sapiens
0.00111
-
 Acetyl-Arg-Pro-Lys-Arg-4-methylcoumarin 7-amide
-
 Homo sapiens
0.00135
-
 acetyl-Tyr-Glu-Lys-Glu-Arg-Ser-Lys-7-amido-4-methylcoumarin
-
 Homo sapiens
0.00159
-
 Acetyl-Lys-Ser-Lys-Arg-4-methylcoumarin 7-amide
-
 Homo sapiens
0.02
-
 Acetyl-Arg-Lys-Lys-Arg-4-methylcoumarin 7-amide
-
 Homo sapiens
0.0403
-
 Acetyl-Arg-Ser-Lys-Arg-4-methylcoumarin 7-amide
-
 Homo sapiens
0.0507
-
 Acetyl-Arg-Phe-Ala-Arg-4-methylcoumarin 7-amide
-
 Homo sapiens