Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Trimeresurus albolabris | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
38800 | - |
native PAGE | Trimeresurus albolabris |
47900 | - |
1 * 47900, SDS-PAGE | Trimeresurus albolabris |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trimeresurus albolabris | - |
from China | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | the enzyme contains about 6% sugar | Trimeresurus albolabris |
Purification (Comment) | Organism |
---|---|
native enzyme 12.7fold from venom to homogeneity by gel filtration, anion exchange and heparin affinity chromatography | Trimeresurus albolabris |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Trimeresurus albolabris | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
108.6 | - |
purified native enzyme, pH 7.4, 37°C, substrate bovine fibrinogen | Trimeresurus albolabris |
192.3 | - |
purified native enzyme, pH 7.4, 37°C, substrate casein | Trimeresurus albolabris |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Bovine fibrinogen + H2O | coagulation | Trimeresurus albolabris | ? | - |
? | |
casein + H2O | high activity | Trimeresurus albolabris | ? | - |
? | |
fibrinogen-releasing peptide A + H2O | the enzyme cleaves the Aalpha- and the Bbeta-chains of fibrinogen-releasing peptides A and B | Trimeresurus albolabris | ? | - |
? | |
fibrinogen-releasing peptide B + H2O | the enzyme cleaves the Aalpha- and the Bbeta-chains of fibrinogen-releasing peptides A and B | Trimeresurus albolabris | ? | - |
? | |
additional information | no activity with fibrin, but high esterase activity with Nalpha-4-tosyl-L-arginine methyl ester | Trimeresurus albolabris | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 47900, SDS-PAGE | Trimeresurus albolabris |
More | the N-terminal sequenceis VVGGDECNIN | Trimeresurus albolabris |
Synonyms | Comment | Organism |
---|---|---|
TA-2 | - |
Trimeresurus albolabris |
Thrombin-like enzyme | - |
Trimeresurus albolabris |
TLE | - |
Trimeresurus albolabris |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Trimeresurus albolabris |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Trimeresurus albolabris |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Trimeresurus albolabris | isoelectric focusing | - |
3.9 |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme acts as a promoter for platelet aggregation induced by ADP or collagen. It causes prolongation of bleeding in mice, but has no hemorrhagic and edema-inducing activities even at high concentrations | Trimeresurus albolabris |