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Literature summary for 3.4.21.74 extracted from

  • Markland, F.S.; Kettner, C.; Schiffman, S.; Shaw, E.; Bajwa, S.S.; Reddy, K.N.N.; Kirakossian, H.; Patkos, G.B.; Theodor, I.; Pirkle, H.
    Kallikrein-like activity of crotalase, a snake venom enzyme that clots fibrinogen (1982), Proc. Natl. Acad. Sci. USA, 79, 1688-1692.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.74

Inhibitors

Inhibitors Comment Organism Structure
Pro-Phe-Arg chloromethyl ketone kinetics Crotalus adamanteus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.06
-
 D-Pro-L-Phe-L-Arg 4-nitroanilide
-
 Crotalus adamanteus
0.14
-
 D-Val-L-Leu-L-Arg 4-nitroanilide
-
 Crotalus adamanteus
0.18
-
 D-Phe-L-pipecoyl-L-Arg 4-nitroanilide
-
 Crotalus adamanteus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 amino acid sequence homology between crotolase, bovine thrombin and porcine pancreatic kallikrein Crotalus adamanteus

Organism

Organism UniProt Comment Textmining
Crotalus adamanteus
-
 Eastern diamondback rattlesnake, formerly EC 3.4.21.30
-

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
 Crotalus adamanteus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Phe-L-pipecoyl-L-Arg 4-nitroanilide + H2O
-
 Crotalus adamanteus ?
-
 ?
D-Pro-L-Phe-L-Arg 4-nitroanilide + H2O
-
 Crotalus adamanteus ?
-
 ?
D-Val-L-Leu-L-Arg 4-nitroanilide + H2O
-
 Crotalus adamanteus ?
-
 ?
H-D-Cyclohexylglycyl-L-2-aminobutyryl-Arg 4-nitroanilide + H2O
-
 Crotalus adamanteus H-D-Cyclohexylglycyl-L-alpha-aminobutyryl-L-arginine + 4-nitroaniline
-
 ?
additional information plasminogen, methoxycarbonyl-cyclohexylglycyl-Gly-Arg 4-nitroanilide Crotalus adamanteus ?
-
 ?