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Literature summary for 3.4.21.73 extracted from

  • Chulsky, S.; Paland, N.; Lazarovich, A.; Fuhrman, B.
    Urokinase-type plasminogen activator (uPA) decreases hepatic SR-BI expression and impairs HDL-mediated reverse cholesterol transport (2014), Atherosclerosis, 233, 11-18.
    View publication on PubMed
Search for more literature for 3.4.21.73

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte primary Homo sapiens
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hepatoma cell
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 Homo sapiens
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Huh-7 cell
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 Homo sapiens
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liver
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
uPA
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 Homo sapiens
Urokinase-type plasminogen activator
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 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme uPA is a serine protease, and together with its membraneassociated receptor uPAR, is part of the uPA/uPAR system, which is an important component of the fibrinolytic system Homo sapiens
physiological function increasing concentrations of the enzyme dose-dependently decrease SR-BI protein expression in the liver and Huh-7 hepatoma cell line..The enzyme decreases both the cellular binding of HDL to Huh-7 hepatocytes, and the selective uptake of HDL-cholesteryl ester from HDL, it decreases the removal of HDL-cholesteryl ester in the liver via suppression of the hepatic SR-BI expression Homo sapiens