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Literature summary for 3.4.21.73 extracted from
- The urokinase plasminogen activator receptor promotes efferocytosis of apoptotic cells (2009), J. Biol. Chem., 284, 17030-17038.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| type-1 plasminogen activator inhibitors | primary endogenous inhibitors | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Urokinase plasminogen activator | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | upregulation of the uPA system is correlated with malignancy of various carcinomas | Homo sapiens |
| physiological function | uPA binds to the urokinase receptor, uPAR, expressed on the surface of many cell types, that coordinates plasmin-mediated cell surface proteolysis for matrix remodeling and promotes cell adhesion by acting as a binding protein for vitronectin. Role of uPAR in the phagocytosis of apoptotic cells, a process termed efferocytosis, overview | Homo sapiens |
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Release 2023.1 (January 2023)
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