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Literature summary for 3.4.21.73 extracted from

  • Sisson, T.H.; Nguyen, M.H.; Yu, B.; Novak, M.L.; Simon, R.H.; Koh, T.J.
    Urokinase-type plasminogen activator increases hepatocyte growth factor activity required for skeletal muscle regeneration (2009), Blood, 114, 5052-5061.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.73

Protein Variants

Protein Variants Comment Organism
additional information mice deficient in uPA show markedly reduced hepatocyte growth factor levels and c-met activation after muscle damage, associated with decreased cell proliferation, myoblast accumulation, and new muscle fiber formation, phenotype, overview. On the other hand, hepatocyte growth factor activity is enhanced at early time points in enzyme inhibitor-deficient PAI-1-/- mice compared with wild-type mice, and the PAI-1-/- animals exhibit accelerated muscle fiber regeneration. Administration of exogenous uPA rescues hepatocyte growth factor levels and muscle regeneration in uPA-/- mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
PAI-1 a proteolytic inhibitor of uPA, blocks the increase in proliferation of myoblasts induced by uPA Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-hepatic growth factor + H2O Mus musculus uPA activates the hepatic growth factor from its inactive single-chain form to the active alpha-chain form mature hepatic growth factor + ?
-
 ?
pro-hepatic growth factor + H2O Mus musculus C57BL/6 uPA activates the hepatic growth factor from its inactive single-chain form to the active alpha-chain form mature hepatic growth factor + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
myoblast
-
 Mus musculus
-
skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-hepatic growth factor + H2O uPA activates the hepatic growth factor from its inactive single-chain form to the active alpha-chain form Mus musculus mature hepatic growth factor + ?
-
 ?
pro-hepatic growth factor + H2O uPA activates the hepatic growth factor from its inactive single-chain form to the active alpha-chain form Mus musculus C57BL/6 mature hepatic growth factor + ?
-
 ?

Synonyms

Synonyms Comment Organism
uPA
-
 Mus musculus
Urokinase-type plasminogen activator
-
 Mus musculus

General Information

General Information Comment Organism
physiological function the plasminogen system plays a crucial role in the repair of a variety of tissues, including skeletal muscle. uPA promotes muscle regeneration by activating hepatocyte growth factor, which, in turn, stimulates proliferation of myoblasts required for regeneration. uPA promotes myoblast proliferation in vitro through its proteolytic activity Mus musculus