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Literature summary for 3.4.21.73 extracted from

  • Spraggon, G.; Phillips, C.; Nowak, U.K.; Ponting, C.P.; Saunders, D.; Dobson, C.M.; Stuart, D.I.; Jones, E.Y.
    The crystal structure of the catalytic domain of human urokinase-type plasminogen activator (1995), Structure, 3, 681-691.
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of the catalytic domain of the recombinant nonglycosylated human uPA, complexed with the inhibitor Glu-Gly-Arg chloromethyl ketone at 2.5 A Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Glu-Gly-Arg chloromethyl ketone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Homo sapiens the enzyme promotes fibrinolysis by catalyzing the conversion of plasminogen to plasmin ?
-
 ?
plasminogen + H2O Homo sapiens when localized to the external cell surface it contributes to tissue remodelling and cellular migration ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?
plasminogen + H2O the enzyme promotes fibrinolysis by catalyzing the conversion of plasminogen to plasmin Homo sapiens ?
-
 ?
plasminogen + H2O when localized to the external cell surface it contributes to tissue remodelling and cellular migration Homo sapiens ?
-
 ?